The study seeks to describe the clinical profile of patients diagnosed with MDR-TB and are enrolled in the PMDT centers in BRTTH, Bicol Medical Center, and Sorsogon Medical Mission Group Hospital Health Services Cooperative. The study identified the risk factors, treatment side effects, and factors that contribute to failure of treatment and non-compliance with the PMDT program. The research design is a prevalence study which shall employ a descriptive research strategy, using a cross-sectional survey research design. It utilized a data collection sheet, clinical charts and interview in its data gathering procedure and data analysis. The duration of the study was for four months, from August 2016 until November 2016. The study revealed that the common clinical profile of an MDR-TB patient from Bicol Regional Training and Teaching Hospital, Bicol Medical Center and Sorsogon Medical Mission Group Hospital Health Services Cooperative is typically male, around the age range of 36 - 50 years old, a high school as the highest educational attainment, married and unemployed, and of lower socio-economic statuses. The MDR-TB prevalence of treatment interruption is high, and most of these patients were for retreatment due to relapse. Treatment interruption can be a possible risk factor for patients developing MDR-TB. The most common side effects reported by these MDR-TB patients are vomiting, dizziness and headaches, and some of them reported the following reasons for treatment interruption, such as Lack of knowledge on treatment, and Distal location of their residence from PMT DOTs centers. Recommendations are provided to increase MDR-TB patients' compliance to treatment, and decrease treatment failure and lost to follow-up.